{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:04:04Z","timestamp":1789988644056,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Biotechnology and Biological Sciences Research Council EASTBIO Doctoral Training Partnership","award":["BB\/J01446X\/1"],"award-info":[{"award-number":["BB\/J01446X\/1"]}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["MR\/M011224\/1"],"award-info":[{"award-number":["MR\/M011224\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Royal Society\/Wolfson"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>The Ess\/Type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> protein secretion system, essential for virulence of pathogenic <jats:italic>Staphylococcus aureus<\/jats:italic>, is dependent upon the four core membrane proteins EssA, EssB, EssC and EsaA. Here, we use crosslinking and blue native <jats:styled-content style=\"fixed-case\">PAGE<\/jats:styled-content> analysis to show that the EssB, EssC and EsaA proteins individually form homomeric complexes. Surprisingly, these components appear unable to interact with each other, or with the EssA protein. We further show that two high molecular weight multimers of EssC detected in whole cells are not dependent upon the presence of EsxA, EsxB or any other Ess component for their assembly.<\/jats:p>","DOI":"10.1002\/1873-3468.12065","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T15:20:50Z","timestamp":1453303250000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Membrane interactions and self\u2010association of components of the Ess\/Type <scp>VII<\/scp> secretion system of <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"590","author":[{"given":"Franziska","family":"J\u00e4ger","sequence":"first","affiliation":[{"name":"Divisions of Molecular Microbiology School of Life Sciences University of Dundee, Dundee 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