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However, the function and regulation mechanism of <jats:styled-content style=\"fixed-case\">ADRB<\/jats:styled-content>3 in the perivascular adipose tissue (<jats:styled-content style=\"fixed-case\">PVAT<\/jats:styled-content>), especially in hypertension, is still unclear. We show that <jats:styled-content style=\"fixed-case\">ADRB<\/jats:styled-content>3 protein is upregulated in the <jats:styled-content style=\"fixed-case\">PVAT<\/jats:styled-content> of deoxycorticosterone acetate\u2010salt (<jats:styled-content style=\"fixed-case\">DOCA<\/jats:styled-content>\u2010salt) hypertensive mice, with the characteristics of <jats:styled-content style=\"fixed-case\">PVAT<\/jats:styled-content> browning and increased uncoupling protein 1 (<jats:styled-content style=\"fixed-case\">UCP<\/jats:styled-content>1) expression. Inhibition of <jats:styled-content style=\"fixed-case\">ADRB<\/jats:styled-content>3 with selective antagonist <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>59230A caused serious vascular injury <jats:italic>in vivo<\/jats:italic>, even though <jats:styled-content style=\"fixed-case\">UCP<\/jats:styled-content>1 expression was downregulated. <jats:styled-content style=\"fixed-case\">ADRB<\/jats:styled-content>3 protein was regulated by let\u20107b, which was decreased in the <jats:styled-content style=\"fixed-case\">PVAT<\/jats:styled-content> of the <jats:styled-content style=\"fixed-case\">DOCA<\/jats:styled-content>\u2010salt group. These data reveal that <jats:styled-content style=\"fixed-case\">ADRB<\/jats:styled-content>3 in <jats:styled-content style=\"fixed-case\">PVAT<\/jats:styled-content> contributes to vascular function in the progression of hypertension.<\/jats:p>","DOI":"10.1002\/1873-3468.12107","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:07:54Z","timestamp":1456373274000},"page":"769-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Beta3 adrenergic receptor is involved in vascular injury in deoxycorticosterone acetate\u2010salt hypertensive mice"],"prefix":"10.1002","volume":"590","author":[{"given":"Li\u2010Juan","family":"Sheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genomics Shanghai Key Laboratory of Hypertension and Department of Hypertension Ruijin Hospital Shanghai Institute of Hypertension Shanghai Jiao Tong University School of Medicine 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