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The main route of\n                    <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>\n                    transmission between humans is through close or direct physical contact, and particularly via respiratory droplets. The upper respiratory tract and skin are major reservoirs for\n                    <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>\n                    infections. The ability of\n                    <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>\n                    to establish an infection in the new host at these anatomical sites primarily results from two distinct physiological processes, namely bacterial adhesion and colonization. These fundamental aspects of pathogenesis rely upon a variety of\n                    <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>\n                    virulence factors, which are usually under strict transcriptional regulation. Considerable progress has been made in better understanding these initial infection steps. This review summarizes our current knowledge of the molecular mechanisms of\n                    <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>\n                    adhesion and colonization.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.12254","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T01:43:02Z","timestamp":1466127782000},"page":"3739-3757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["<i>Streptococcus pyogenes<\/i>\n                    adhesion and colonization"],"prefix":"10.1002","volume":"590","author":[{"given":"Stephan","family":"Brouwer","sequence":"first","affiliation":[{"name":"Australian Infectious Diseases Research Centre School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy 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