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To withstand the degradation by its host cells, a <jats:italic>Legionella<\/jats:italic>\u2010containing vacuole (LCV) is established for intracellular replication, and numerous effector proteins are secreted into the host cytosol using a type four B secretion system (T4BSS). During intracellular replication, <jats:italic>Legionella<\/jats:italic> has a biphasic developmental cycle that alternates between a replicative and a transmissive form. New knowledge about the host\u2010adapted and life stage\u2010dependent metabolism of intracellular <jats:italic>L.\u00a0pneumophila<\/jats:italic> revealed a bipartite metabolic network with life stage\u2010specific usages of amino acids (e.g. serine), carbohydrates (e.g. glucose) and glycerol as major substrates. 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