{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:49:20Z","timestamp":1790596160241,"version":"4.1.0"},"reference-count":119,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Nontypeable <jats:italic>Haemophilus influenzae<\/jats:italic> (<jats:styled-content style=\"fixed-case\">NTH<\/jats:styled-content>i) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against <jats:italic>H. influenzae<\/jats:italic> serotype b in the 1990s, the burden of <jats:italic>H. influenzae<\/jats:italic>\u2010related infections has been increasingly dominated by <jats:styled-content style=\"fixed-case\">NTH<\/jats:styled-content>i. Understanding the ability of <jats:styled-content style=\"fixed-case\">NTH<\/jats:styled-content>i to cause infection is currently an expanding area of study. <jats:styled-content style=\"fixed-case\">NTH<\/jats:styled-content>i is able to exert differential binding to the host tissue through the use of a broad range of adhesins. <jats:styled-content style=\"fixed-case\">NTH<\/jats:styled-content>i survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.<\/jats:p>","DOI":"10.1002\/1873-3468.12351","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T12:52:36Z","timestamp":1470833556000},"page":"3840-3853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Host\u2013pathogen interactions of nontypeable <i>Haemophilus influenzae<\/i>: from commensal to pathogen"],"prefix":"10.1002","volume":"590","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-8909","authenticated-orcid":false,"given":"Benjamin Luke","family":"Duell","sequence":"first","affiliation":[{"name":"Clinical Microbiology Department of Translational Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ching","family":"Su","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Department of Translational Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Riesbeck","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Department of Translational Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.34.1.97"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00103-13"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.1.75"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31823aaeb3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.52.1.183-191.1986"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03448-13"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00940-08"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036226"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.05.020415"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S32330"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70734-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.150004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181950c74"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.2306029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000066798.69778.07"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1742-1241.2003.tb10589.x","article-title":"Nasopharyngeal carriage rate of Haemophilus influenzae in children aged 7\u201012 years in Turkey","volume":"57","author":"Ayyildiz A","year":"2003","journal-title":"Int J Clin Pract"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.524-529.2004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000500016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.12.045"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.17.46.20313-en"},{"key":"e_1_2_10_22_1","first-page":"179","article-title":"Carriage rate of Haemophilus influenzae among preschool children in Turkey","volume":"60","author":"Oguzkaya\u2010Artan M","year":"2007","journal-title":"Jpn J Infect Dis"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.03.026"},{"key":"e_1_2_10_24_1","first-page":"938","article-title":"Prevalence and serotype distribution of Haemophilus influenzae strains isolated from community\u2010acquired lower respiratory tract infections in Poland","volume":"43","author":"Skoczynska A","year":"2003","journal-title":"Abstr Intersci Conf Antimicrob Agents Chemother"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.1033"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/317538"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-007-0599-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150140"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303449"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501197"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01636-13"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.10.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2011.00001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12203"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12073"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.317"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-859OC"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.5.1710-1718.1994"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000056"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.1.364-368.1998"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403353111"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.2875"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01765-15"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.9.4028-4033.1994"},{"key":"e_1_2_10_46_1","first-page":"283","article-title":"Function of proteoglycans in the extracellular matrix","volume":"43","author":"Yanagishita M","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/12.4.43R"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00266.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.4902-4907.2002"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099066"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1437"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir459"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.10.006"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/596211"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1086\/649782"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803226"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0600-8"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis754"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv374"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12575"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3362-3367.2000"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.4.1477-1479.1996"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2015.12.006"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8828"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.58.12.4036-4044.1990"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00598-09"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005576"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.10.3379"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2001.0456"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00942-12"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05460.x"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01313-10"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00864-13"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149891"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2001.00132.x"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.040451-0"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00492-13"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0231-y"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05332-11"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01227-12"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003709"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308125100"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2003.08.007"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.05.002"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00042"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.04.015"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105644"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.5"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12741"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01224-13"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2728-2735.2005"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00185-13"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00063-14"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002521"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00079-12"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.1002"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01478-14"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12164"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.12.005"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3525"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3837"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.08.102"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.10"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042664"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.13.1710"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01691-06"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.106-113.2004"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1828-1836.2006"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01445-13"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01935-06"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.06540-11"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02601-14"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339961"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.27"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12195"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00058"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01973-14"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123154"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2014.04.010"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.12351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.12351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.12351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:00:12Z","timestamp":1694516412000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":119,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/1873-3468.12351"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.12351","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]},"assertion":[{"value":"2016-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}