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The availability of nutrients, as well as changes in oxygen, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and interferon\u2010\u03b3 levels, have been shown to directly influence the chlamydial life cycle and clearance. Although the lung has been traditionally regarded as a sterile environment, sequencing approaches have enabled the identification of a large number of bacteria in healthy and diseased lungs. The influence of the lung microbiota on respiratory infections has not been extensively studied so far and data on chlamydial infections are currently unavailable. In the present study, we speculate on how lung microbiota might interfere with acute and chronic infections by focusing exemplarily on the obligate intracellular <jats:italic>C.\u00a0pneumoniae<\/jats:italic>. 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