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Bot <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>, which consists of 70 amino acids, is a highly atypical toxin. It carries a unique N\u2010terminal sequence extension and is highly lethal in mice. Voltage clamp recordings on oocytes expressing rat Nav1.2 or insect BgNav1 reveal that, similar to other \u03b1\u2010like toxins, Bot <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> inhibits fast inactivation of both variants. Moreover, Bot <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> belongs to the same structural\/immunological group as the \u03b1\u2010like toxin Bot I. Remarkably, radioiodinated Bot <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> competes efficiently with the classical \u03b1\u2010toxin AaH <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> from <jats:italic>Androctonus australis,<\/jats:italic> and displays one of the highest affinities for Nav channels.<\/jats:p>","DOI":"10.1002\/1873-3468.12357","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T07:25:07Z","timestamp":1471332307000},"page":"3221-3232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The scorpion toxin Bot <scp>IX<\/scp> is a potent member of the \u03b1\u2010like family and has a unique N\u2010terminal sequence extension"],"prefix":"10.1002","volume":"590","author":[{"given":"Marie\u2010France","family":"Martin\u2010Eauclaire","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9 CNRS CRN2M UMR7286 PFRN\u2010CAPM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Salvatierra","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bosmans","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Johns Hopkins University Baltimore MD USA"},{"name":"Solomon H. 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