{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:11:46Z","timestamp":1786975906066,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14\u201015\u201000618"],"award-info":[{"award-number":["14\u201015\u201000618"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    In this study, we investigated the effects of L\u2010homocysteine (Hcy) on maxi calcium\u2010activated potassium (\n                    <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\n                    ) channels and on exocytosis of secretory granules in\n                    <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\n                    3 rat pituitary\u2010derived cells. A major finding of our study indicates that short\u2010term application of Hcy increased the open probability of oxidized\n                    <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\n                    channels in inside\u2010out recordings. Whole\u2010cell recordings show that extracellular Hcy also augmented\n                    <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\n                    currents during long\u2010term application. Furthermore, Hcy decreased the exocytosis of secretory granules. This decrease was partially prevented by the\n                    <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\n                    channel inhibitor paxilline and fully prevented by N\u2010acetylcysteine, a reactive oxygen species scavenger. Taken together, our data show that elevation of cellular Hcy level induces oxidative stress, increases\n                    <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\n                    channel activity, and decreases exocytosis of secretory granules. These findings may provide insight into some of the developmental impairments and neurotoxicity associated with Hyperhomocysteinemia (\n                    <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>\n                    cy), a disease arising due to abnormally elevated levels of Hcy in the plasma.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.12381","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T22:12:01Z","timestamp":1472767921000},"page":"3375-3384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Homocysteine augments\n                    <scp>BK<\/scp>\n                    channel activity and decreases exocytosis of secretory granules in rat\n                    <scp>GH<\/scp>\n                    3 cells"],"prefix":"10.1002","volume":"590","author":[{"given":"Aisylu 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