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The purpose of this study was to identify receptors on HSC for HSC\u2010derived exosomes, which bind to HSC rather than to hepatocytes. Our findings indicate that exosome binding to HSC is blocked by treating HSC with RGD, EDTA, integrin \u03b1v or \u03b21 siRNAs, integrin \u03b1v\u03b23 or \u03b15\u03b21 neutralizing antibodies, heparin, or sodium chlorate. Furthermore, exosome cargo delivery and exosome\u2010regulated functions in HSC, including expression of fibrosis\u2010 or activation\u2010associated genes and\/or miR\u2010214 target gene regulation, are dependent on cellular integrin \u03b1v\u03b23, integrin \u03b15\u03b21, or heparan sulfate proteolgycans (HSPG). 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