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Although the specific function of \u03b1\u2010Syn is still unclear, its high structural plasticity is key for the interactions of \u03b1\u2010Syn with biological membranes. Recently, it has been observed that \u03b1\u2010Syn is able to form high\u2010density lipoprotein\u2010like (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010like) particles that are reminiscent of self\u2010assembling phospholipid bilayer nanodiscs. Here, we extended our preparation method for the production of \u03b1\u2010Syn lipoprotein particles to the \u03b2\u2010 and \u03b3\u2010Syn variants, and the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010related familial \u03b1\u2010Syn mutants. We show that all human Syns can form stable and homogeneous populations of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010like particles with distinct morphologies. Our results characterize the impact of the individual Syns on the formation capacity of these particles and indicate that Syn <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010like particles are neither causing toxicity nor a toxicity\u2010related loss of \u03b1\u2010Syn in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/1873-3468.12543","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T21:35:19Z","timestamp":1482874519000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High\u2010density lipoprotein\u2010like particle formation of Synuclein variants"],"prefix":"10.1002","volume":"591","author":[{"given":"C\u00e9dric","family":"Eichmann","sequence":"first","affiliation":[{"name":"In\u2010Cell NMR Laboratory Department of NMR\u2010supported Structural Biology Leibniz Institute of Molecular Pharmacology (FMP Berlin) Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry Swiss Federal Institute of Technology Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Riek","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry Swiss Federal Institute of Technology Z\u00fcrich 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