{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:53:27Z","timestamp":1792511607792,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372418"],"award-info":[{"award-number":["31372418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The vascular endothelial (<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>)\u2010cadherin functions as an endothelial barrier protein controlling endothelial permeability and leukocyte transmigration. Developmental studies indicate that <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\u2010cadherin also plays a vital role in angiogenesis. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u201022 plays important roles in cardiovascular diseases including cardiac hypertrophy and heart failure. We identified that miR\u201022 interacts with <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\u2010cadherin <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>. Overexpression of miR\u201022 in endothelial cells increases the synthesis of proinflammatory cytokines. Injection of miR\u201022 results in increased myeloperoxidase activity in the mouse lungs. Moreover, miR\u201022 injection into the fluorescent\u2010labeled transgenic zebrafish Tg(fli1:<jats:styled-content style=\"fixed-case\">EGFP<\/jats:styled-content>) embryos caused defective vascular development in the dorsal and intersegmental vessels, and vascular markers were significantly suppressed in these embryos. Our studies demonstrate that the conserved targeting of <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\u2010cadherin by miR\u201022 regulates endothelial inflammation, tissue injury, and angiogenesis.<\/jats:p>","DOI":"10.1002\/1873-3468.12565","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T12:02:45Z","timestamp":1485172965000},"page":"513-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Micro<scp>RNA<\/scp>\u201022 regulates inflammation and angiogenesis <i>via<\/i> targeting <scp>VE<\/scp>\u2010cadherin"],"prefix":"10.1002","volume":"591","author":[{"given":"Wei","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fresh Water Animal Breeding College of Fisheries Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiping","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fresh Water Animal Breeding College of Fisheries Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.08.020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394311-8.00006-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv145"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(96)84935-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81010-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.10.2093"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.02.057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005772"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008807"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060308-103103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2011.06.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23091"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-473017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4796-12.2013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.68"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052588"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07594.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605895"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000594"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.06.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.026"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01875-08"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds031"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2300"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11452"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0872-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300682"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075882"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00037.2015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058857"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-114"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366358"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431367"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3292"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3555"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4575-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20102"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.12565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.12565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:50:47Z","timestamp":1694825447000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/1873-3468.12565"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.12565","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"2016-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}