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Global gene expression analysis with immunohistochemical staining and calcium flux assays reveal the generation of neurons from mouse embryonic fibroblasts. In addition, time\u2010lapse imaging of neural precursor\u2010specific enhancer expression and global gene expression analyses show that the neurons are generated by passing through a neural crest\u2010like precursor stage. Consistent with these results, the neural crest\u2010like cells are able to differentiate into neural crest lineage cells, such as sympathetic neurons, adipocytes, osteocytes, and smooth muscle cells. 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