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We identified and chemically characterised the dehydrorotenoid boeravinone H, isolated from the herb <jats:italic>Boerhavia\u00a0diffusa<\/jats:italic>, as a new inhibitor of HCV entry. The compound significantly inhibits the binding and entry of hepatitis C\u2010like particles (HCV\u2010LPs) in hepatoma cells <jats:italic>in\u00a0vitro<\/jats:italic> with no apparent cytotoxicity. Boeravinone H inhibits the initial phase of HCV entry probably by acting directly on the viral particle. Importantly, the compound prevents HCV entry and infection in cell culture (<jats:italic>ex\u00a0vivo<\/jats:italic>). Thus, boeravinone H is a potential antiviral agent for the prevention and control of HCV infection.<\/jats:p>","DOI":"10.1002\/1873-3468.12629","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T12:14:47Z","timestamp":1490357687000},"page":"1305-1317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A plant\u2010derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry"],"prefix":"10.1002","volume":"591","author":[{"given":"Mihika","family":"Bose","sequence":"first","affiliation":[{"name":"Department of Biochemistry Indian Institute of Science Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohini","family":"Kamra","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Indian Institute of Science Bangalore 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