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Here, we provide evidence that indicates that this decrease is associated with the\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    \u2010linked angiopathy. While wild\u2010type mice of different ages show upregulated cerebral neuroglobin expression upon whole\u2010body hypoxia,\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    23 mice exhibit decreased cerebral transcription of neuroglobin. Interestingly, transcription of cytoglobin, whose involvement in amyloid pathology still needs to be elucidated, follows a similar pattern. To further unravel the underlying mechanism, we examined the expression levels of the\n                    <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>\n                    \u20101\u2010silencing transcription factor (\n                    <jats:styled-content style=\"fixed-case\">REST<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">NRSF<\/jats:styled-content>\n                    ) after identifying a recognition site for it in the regulatory region of both globins. Neuroglobin\u2010cytoglobin\u2010\n                    <jats:styled-content style=\"fixed-case\">REST<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">NRSF<\/jats:styled-content>\n                    expression correlations are detected mainly in the cortex. This raises the possibility of\n                    <jats:styled-content style=\"fixed-case\">REST<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">NRSF<\/jats:styled-content>\n                    being an upstream regulator of these globins.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.12651","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T02:56:46Z","timestamp":1491706606000},"page":"1321-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impaired hypoxic tolerance in\n                    <scp>APP<\/scp>\n                    23 mice: a dysregulation of neuroprotective globin levels"],"prefix":"10.1002","volume":"591","author":[{"given":"Zo\u00eb P.","family":"Van Acker","sequence":"first","affiliation":[{"name":"Laboratory of Protein Science, Proteomics and Epigenetic Signalling Department of 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