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Our previous studies have demonstrated the therapeutic effects of <jats:styled-content style=\"fixed-case\">HNF<\/jats:styled-content>1\u03b1 on hepatic fibrosis and hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in animals. In this study, we created hepatocyte\u2010specific <jats:italic>Hnf1<\/jats:italic>\u03b1 knockout mice using the Cre\u2010<jats:italic>loxP<\/jats:italic> recombination system. The knockout mice display increased fatty acid synthesis in the liver. Moreover, these mice spontaneously develop <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> through fatty liver without cirrhosis. Inflammatory cytokines, such as tumor necrosis factor \u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, are upregulated and accompanied by increased phosphorylation of Akt, p\u201065 and <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 in the livers of <jats:styled-content style=\"fixed-case\">HNF<\/jats:styled-content>1\u03b1 knockout mice. Our findings suggest that <jats:styled-content style=\"fixed-case\">HNF<\/jats:styled-content>1\u03b1 plays a crucial role in hepatocyte lipid metabolism and hepatocarcinogenesis.\n<\/jats:p>","DOI":"10.1002\/1873-3468.12689","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T07:46:48Z","timestamp":1495784808000},"page":"1947-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Deletion of <i><scp>HNF<\/scp>1<\/i>\u03b1 in hepatocytes results in fatty liver\u2010related hepatocellular carcinoma in mice"],"prefix":"10.1002","volume":"591","author":[{"given":"Qi","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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