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The fruit fly <jats:italic>Drosophila<\/jats:italic>\u00a0<jats:italic>melanogaster<\/jats:italic> is thought to have a slightly smaller <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content> complex comprised of <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content>, Gemin2\/3\/5 and, possibly, Unrip. Based upon <jats:italic>in\u00a0vivo<\/jats:italic> interaction methods, we have identified novel interacting partners of the <jats:italic>Drosophila <\/jats:italic><jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content> complex with homologies to Gemin4\/6\/7\/8. The Gemin4 and Gemin8 orthologues are required for neuromuscular function and survival. The Gemin6\/7\/Unrip module can be recruited via the <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content>\u2010associated Gemin8, hence mirroring the human <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content> complex architecture. Our findings lead us to propose that an elaborate <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content> complex that is typical in metazoans is also present in <jats:italic>Drosophila<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/1873-3468.12853","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T12:58:44Z","timestamp":1506430724000},"page":"3600-3614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Novel interactors of the <i>Drosophila<\/i> Survival Motor Neuron (SMN) Complex suggest its full conservation"],"prefix":"10.1002","volume":"591","author":[{"given":"Maia","family":"Lanfranco","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier CNRS\u2010UMR 5535 Universit\u00e9 de Montpellier France"},{"name":"Department of Physiology and Biochemistry Faculty of Medicine and Surgery University of Malta Msida 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