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This metabolic regulation seems to be accompanied by morphologic adaptation of muscle fibers toward the glycolytic fiber type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> with the concomitant upregulation of mitochondrial fatty acid biosynthesis (<jats:styled-content style=\"fixed-case\">mFASII<\/jats:styled-content>) and lipoic acid biosynthesis. Dietary supplementation of <jats:styled-content style=\"fixed-case\">VLCAD<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice with different medium\u2010chain triglycerides over 1 year revealed that odd\u2010chain species has no effect on muscle fiber switch, whereas even\u2010chain species inhibit progressive metabolic adaptation. Our study shows that muscle may undergo adaptive mechanisms that are modulated by dietary supplementation. 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