{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:58:12Z","timestamp":1792155492765,"version":"4.4.0"},"reference-count":138,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM110424"],"award-info":[{"award-number":["GM110424"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG026389"],"award-info":[{"award-number":["AG026389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS065789"],"award-info":[{"award-number":["NS065789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TR000503"],"award-info":[{"award-number":["TR000503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS101628"],"award-info":[{"award-number":["NS101628"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    The mitochondrial transcription factor A, or\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    , is a mitochondrial\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    (mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    )\u2010binding protein essential for genome maintenance.\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    functions in determining the abundance of the mitochondrial genome by regulating packaging, stability, and replication. More recently,\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    has been shown to play a central role in the mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    stress\u2010mediated inflammatory response. Emerging evidence indicates that decreased mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    copy number is associated with several aging\u2010related pathologies; however, little is known about the association of\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    abundance and disease. In this Review, we evaluate the potential associations of altered\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    levels or mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    copy number with neurodegeneration. We also describe potential mechanisms by which mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    replication, transcription initiation, and\n                    <jats:styled-content style=\"fixed-case\">TFAM<\/jats:styled-content>\n                    \u2010mediated endogenous danger signals may impact mitochondrial homeostasis in Alzheimer, Huntington, Parkinson, and other neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.12989","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T09:56:39Z","timestamp":1516787799000},"page":"793-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":304,"title":["The mitochondrial transcription factor\n                    <scp>TFAM<\/scp>\n                    in neurodegeneration: emerging evidence and mechanisms"],"prefix":"10.1002","volume":"592","author":[{"given":"Inhae","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Jeju National University Korea"},{"name":"Division of Cardiology Department of Medicine Center for Metabolic and Mitochondrial Medicine (C3M) Vascular Medicine Institute University of Pittsburgh School of Medicine PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charleen T.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pathology Center for Neuroscience Pittsburgh Institute for Neurodegenerative Diseases Conformational Protein Diseases Center McGowan Institute for Regenerative Medicine University of Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Center for Metabolic and Mitochondrial Medicine (C3M) Vascular Medicine Institute University of Pittsburgh School of Medicine PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05293"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05291"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20624"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1448"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr239"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13731"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.06.052"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9766-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9618-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26966"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.10.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12494"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14893"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612283113"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500624112"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq430"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21831"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20713"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.07.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16983-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3525-12.2013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1126"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091416-035426"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.07.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(06)77005-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb02325.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.2.333"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540701509955"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bdq.2017.08.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.212753"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/586017"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2012.03.002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0470069"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001917"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27794"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.09.019"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.4.1309"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.10.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39184-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg717"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2159"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4077"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2160"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr787"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512131112"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-05-0404"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1157"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.751008"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.036"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1356"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv235"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014402"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.409"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.03.027"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074513"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg251"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf099"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.22.9823-9834.2004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008924107"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.023"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600963"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-231"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.10.003"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh109"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl703"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.046"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.04.008"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00076.2008"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)03008-5"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.02.010"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23890"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.21"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.09.005"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.09.013"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1769"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.08.008"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90497-B"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920209789503879"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23568"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403649101"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03053.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/383170"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100351"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.04.508"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0404-6"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-21"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9703"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr043"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.07.002"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.524835"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119687"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08176.x"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1957-08.2008"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23000"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07094.x"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37889"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq306"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131715"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24571"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80405-5"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.09.004"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh175"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq229"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100488"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00278-7"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.06.008"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.11.016"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07581.x"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797397"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400784"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.10.022"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.025"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9522-6"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64487-2"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00478.x"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6458"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.46"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.11.037"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.10.045"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.070"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.010"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.074"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-08082.2001"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605208103"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00542.x"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103295108"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-173625"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.08.143"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.003"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.08.007"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2009.023"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6206"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq531"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.02.062"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-32"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.12989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.12989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T01:43:06Z","timestamp":1694482986000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":138,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/1873-3468.12989"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.12989","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]},"assertion":[{"value":"2017-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}