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Mutations in its gene result in Lafora disease, a fatal progressive myoclonus epilepsy, the hallmark being water\u2010insoluble, hyperphosphorylated carbohydrate inclusions called Lafora bodies. Human laforin consists of an N\u2010terminal carbohydrate\u2010binding module (<jats:styled-content style=\"fixed-case\">CBM<\/jats:styled-content>) from family <jats:styled-content style=\"fixed-case\">CBM<\/jats:styled-content>20 and a C\u2010terminal dual\u2010specificity phosphatase domain. Laforin is conserved in all vertebrates, some basal metazoans and a small group of protozoans. The present <jats:italic>in silico<\/jats:italic> study defines the evolutionary relationships among the <jats:styled-content style=\"fixed-case\">CBM<\/jats:styled-content>20s of laforin with an emphasis on newly identified laforin orthologues. 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