{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:23Z","timestamp":1790937143669,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"am","delay-in-days":364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE\u2010FG02\u201011ER16220"],"award-info":[{"award-number":["DE\u2010FG02\u201011ER16220"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Inhibitors of the mitochondrial respiratory chain cytochrome <jats:italic>bc<\/jats:italic><jats:sub>1<\/jats:sub> complex, such as the antimalarial atovaquone and <jats:styled-content style=\"fixed-case\">ELQ<\/jats:styled-content>\u2010300, and many well\u2010studied compounds, are classified as either <jats:italic>Q<\/jats:italic><jats:sub>o<\/jats:sub> or <jats:italic>Q<\/jats:italic><jats:sub>i<\/jats:sub> site inhibitors based on their site of action. Here, we investigated the site of action of <jats:styled-content style=\"fixed-case\">ELQ<\/jats:styled-content>\u2010400 that showed an unusual behaviour, being effective against parasites resistant to the <jats:italic>Q<\/jats:italic><jats:sub>o<\/jats:sub>\u00a0site inhibitor atovaquone or to the <jats:italic>Q<\/jats:italic><jats:sub>i<\/jats:sub> site inhibitor <jats:styled-content style=\"fixed-case\">ELQ<\/jats:styled-content>\u2010300. Analysis of yeast mutants and comparison with atovaquone and other <jats:styled-content style=\"fixed-case\">ELQ<\/jats:styled-content>s strongly suggest that <jats:styled-content style=\"fixed-case\">ELQ<\/jats:styled-content>\u2010400 targets both <jats:italic>Q<\/jats:italic><jats:sub>o<\/jats:sub>\u00a0and <jats:italic>Q<\/jats:italic><jats:sub>i<\/jats:sub>\u00a0sites. Dual site inhibition would be particularly efficient as it would lower the risk of acquired resistance. However, such compounds are seldom found, which could be explained by structural and mechanistic differences between the sites.<\/jats:p>","DOI":"10.1002\/1873-3468.13035","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:01:27Z","timestamp":1521990087000},"page":"1346-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The antimalarial compound <scp>ELQ<\/scp>\u2010400 is an unusual inhibitor of the <i>bc<\/i><sub>1<\/sub> complex, targeting both <i>Q<\/i><sub>o<\/sub> and <i>Q<\/i><sub>i<\/sub> sites"],"prefix":"10.1002","volume":"592","author":[{"given":"Zehua","family":"Song","sequence":"first","affiliation":[{"name":"Translational Research Institute Henan Provincial People's Hospital School of Medicine Henan University Zhengzhou China"},{"name":"Institute for Integrative Biology of the Cell (I2BC) CEA CNRS Universit\u00e9 Paris\u2010Sud Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan I.","family":"Iorga","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles CNRS UPR 2301 Labex LERMIT Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mounkoro","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC) CEA CNRS Universit\u00e9 Paris\u2010Sud Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fisher","sequence":"additional","affiliation":[{"name":"MSU\u2010DOE Plant Research Laboratory Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Meunier","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC) CEA CNRS Universit\u00e9 Paris\u2010Sud Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(76)90124-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.02.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(86)26026-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2007.00328.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2100-2108.2000"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00184-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01515.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/318835"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5029"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.07.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm087"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00710-15"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208069109"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04149-14"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416611112"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00486-12"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500147k"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01866-16"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0553"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2725-2731.2003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313866200"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-028-7_5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10465"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2015.08.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071726"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502319200"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710126200"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0342160"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.03.009"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7481-9_21"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.032102.150251"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.01.009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702621104"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300265"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi400624m"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0341814"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.12.003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324319"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00791-16"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80373-0"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.13035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.13035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/1873-3468.13035","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:06:33Z","timestamp":1694354793000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.13035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/1873-3468.13035"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.13035","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"2018-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}