{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:08:52Z","timestamp":1792642132134,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The chemical biology of thiols (RSH, e.g., cysteine and cysteine\u2010containing proteins\/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure\/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol\/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS<jats:sub>n<\/jats:sub>H, RSS<jats:sub>n<\/jats:sub>R, <jats:italic>n<\/jats:italic> &gt; 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS<jats:sub>n<\/jats:sub>H. RSSH of cysteine (Cys\u2010SSH) has been found to be prevalent in mammalian systems along with Cys\u2010SSH\u2010containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys\u2010SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.<\/jats:p>","DOI":"10.1002\/1873-3468.13090","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T01:25:03Z","timestamp":1526174703000},"page":"2140-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":216,"title":["Biological hydropersulfides and related polysulfides \u2013 a new concept and perspective in redox biology"],"prefix":"10.1002","volume":"592","author":[{"given":"Jon M.","family":"Fukuto","sequence":"first","affiliation":[{"name":"Department of Chemistry Sonoma State University Rohnert Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Ignarro","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology Center for the Health Sciences UCLA 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