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As sickled and normal erythrocytes contain high cholesterol: phospholipid ratio, we investigated the role of lipid composition, chain length, and unsaturation on the partitioning and leakage of hemin in phospholipid vesicles. To establish structure\u2010activity relationship in membrane damage, experiments with two other analogues, protoporphyrin\u2010<jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> and hematoporphyrin (HP) were also carried out. Hemin and its analogues localize differently in membranes and exhibit distinct roles in partitioning, leakage and fusion. Hemin and HP trigger more leakage in the presence of aminophospholipids, whereas cholesterol buffers the destabilizing effect remarkably. Inhibition of fusion by hemin further suggests its unexplored and important role in membrane trafficking, particularly under diseased conditions.<\/jats:p>","DOI":"10.1002\/1873-3468.13165","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T11:07:42Z","timestamp":1529492862000},"page":"2458-2465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structure\u2010activity relationship of heme and its analogues in membrane damage and inhibition of fusion"],"prefix":"10.1002","volume":"592","author":[{"given":"Debashree","family":"Das","sequence":"first","affiliation":[{"name":"Biophysics &amp; Structural Genomics Division Saha Institute of Nuclear Physics Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-950X","authenticated-orcid":false,"given":"Pradip 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