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Phenobarbital (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>), a clinical sedative, activates <jats:italic>Sult1e1<\/jats:italic> gene transcription in mouse livers. Here, the molecular mechanism by which the nuclear receptors <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>, which is targeted by <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1 communicate through phosphorylation to regulate <jats:italic>Sult1e1<\/jats:italic> activation has been studied. <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1, a basal activity repressor of the <jats:italic>Sult1e1<\/jats:italic> promoter, becomes phosphorylated at serine 100 and converts to an activator of the <jats:italic>Sult1e1<\/jats:italic> promoter in response to <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> regulates both the <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1 phosphorylation and conversion. Our findings suggest that <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> signals <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> to communicate with <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1 <jats:italic>via<\/jats:italic> serine 100 phosphorylation, converting <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1 from transcription repressor to activator of the <jats:italic>Sult1e1<\/jats:italic> gene and inducing <jats:styled-content style=\"fixed-case\">SULT<\/jats:styled-content>1E1 expression in mouse livers.<\/jats:p>","DOI":"10.1002\/1873-3468.13199","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T18:51:39Z","timestamp":1532026299000},"page":"2760-2768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Phenobarbital\u2010induced phosphorylation converts nuclear receptor 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