{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:36:11Z","timestamp":1776342971815,"version":"3.51.2"},"reference-count":51,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["128566"],"award-info":[{"award-number":["128566"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["71"],"award-info":[{"award-number":["71"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    During spermatogenesis, fatty acids play an important role both as structural components and messengers that trigger male germ cell line differentiation. The spontaneous oxidation of fatty acids causes a decrease in mammalian fertility. Here, we examine the effects of nonenzymatically oxidized arachidonic acid (AA\n                    <jats:sub>ox<\/jats:sub>\n                    ) on mouse spermatogenic T\u2010type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    currents (I\n                    <jats:sub>CaT<\/jats:sub>\n                    ) due to their physiological relevance during spermatogenesis. AA\n                    <jats:sub>ox<\/jats:sub>\n                    is 25\u2010fold more potent than AA at inhibiting I\n                    <jats:sub>CaT<\/jats:sub>\n                    and it left shifts the I\u2010V curve peak and both activation and steady\u2010state inactivation curves. In addition, I\n                    <jats:sub>CaT<\/jats:sub>\n                    deactivation kinetics and their recovery from inactivation are slower in the presence of AA\n                    <jats:sub>ox<\/jats:sub>\n                    . Therefore, the fraction of inactivated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels is increased. AA\n                    <jats:sub>ox<\/jats:sub>\n                    \u2010induced I\n                    <jats:sub>CaT<\/jats:sub>\n                    inhibition could contribute to male infertility affecting Ca\n                    <jats:sup>2+<\/jats:sup>\n                    regulation in spermatogenic cells.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.13448","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T07:29:44Z","timestamp":1558510184000},"page":"1735-1750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nonenzymatically oxidized arachidonic acid regulates T\u2010type Ca\n                    <sup>2+<\/sup>\n                    currents in mouse spermatogenic cells"],"prefix":"10.1002","volume":"593","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-2627","authenticated-orcid":false,"given":"Olga","family":"Bondarenko","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-1622","authenticated-orcid":false,"given":"Gerardo","family":"Corzo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix L.","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-0567","authenticated-orcid":false,"given":"Federico","family":"del R\u00edo\u2010Portilla","sequence":"additional","affiliation":[{"name":"Departamento de Biomacromol\u00e9culas. Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-0505","authenticated-orcid":false,"given":"Alberto","family":"Darszon","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-0258","authenticated-orcid":false,"given":"Ignacio","family":"L\u00f3pez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1583"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00257-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.100255"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R032326"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080420311"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod51.1.140"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158518"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13210"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod27.2.312"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.216"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.09.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1973.0035"},{"key":"e_1_2_8_15_1","first-page":"317","article-title":"Lipid peroxides in spermatozoa; formation, role of plasmalogen, and physiological significance","volume":"30","author":"Jones R","year":"1976","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0500261"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1978.0053"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43999-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12656"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2572073","article-title":"Enhanced protective effects of combined treatment with \u03b2 \u2010carotene and curcumin against hyperthermic spermatogenic disorders in mice","volume":"2016","author":"Lin C","year":"2016","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0624-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9478-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1910289"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1987.tb00973.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod12.5.641"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120240206"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1993.tb01177.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120230108"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327113489052"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2014.09.003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2015.11.021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00497.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304437200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.334896"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4182"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409050"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200810047"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.03.015"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.1.H184"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.08.032"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.11.022"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.22903"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.3.R607"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12255"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25112"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01688-4"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172128"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-06856.2002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232715"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00391.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00673-3"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.13448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.13448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:08:18Z","timestamp":1694250498000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.13448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":51,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/1873-3468.13448"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.13448","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/586297","asserted-by":"object"}]},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]},"assertion":[{"value":"2019-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}