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PCC 7120 is an important model organism for studying cell differentiation, nitrogen fixation, and photosynthesis. This cyanobacterium possesses a high number of membrane transporters. Not much is known about the roles of the membrane transporters, especially the ATP\u2010binding cassette (ABC) transporters, in the multidrug resistance of this cyanobacterium. In the present work, we performed a mutational analysis of the genes <jats:italic>alr4280\/alr4281\/alr4282<\/jats:italic> and <jats:italic>alr3647\/alr3648\/alr3649<\/jats:italic> that code for the components of putative ABC exporters and are homologous to the DevBCA heterocyst\u2010specific glycolipid exporter. 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