{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:16:06Z","timestamp":1778699766653,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Nuclear receptor\u2010binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown. In this study, we found that NSD3 expression is reduced by isoproterenol (ISO) stimuli both <jats:italic>in\u00a0vitro<\/jats:italic> and <jats:italic>in\u00a0vivo<\/jats:italic>. Overexpression of NSD3 attenuates ISO\u2010induced cardiomyocyte hypertrophy. Mechanistically, ISO treatment decreases H3K27me2\/3 modifications on the atrial natriuretic factor (ANF) promoter by suppressing NSD3 and inhibits the association between NSD3 and bromodomain\u2010containing protein 4 (BRD4), thus suppressing the BRD4\u2010mediated H3K27ac modifications, which ultimately promote ANF transcription and cardiomyocyte hypertrophy. In conclusion, NSD3 decreases ANF expression and, thereby, attenuates ISO\u2010induced cardiomyocyte hypertrophy.<\/jats:p>","DOI":"10.1002\/1873-3468.13515","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T11:34:01Z","timestamp":1561808041000},"page":"2556-2565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective effect of histone methyltransferase NSD3 on ISO\u2010induced cardiac hypertrophy"],"prefix":"10.1002","volume":"593","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology Fuwai Central China Cardiovascular Hospital &amp; Henan Provincial People's Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Central China Cardiovascular Hospital &amp; Henan Provincial People's Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Central China Cardiovascular Hospital &amp; 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