{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:54:37Z","timestamp":1784879677126,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18\u201004\u201001366"],"award-info":[{"award-number":["18\u201004\u201001366"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18\u201054\u201054006"],"award-info":[{"award-number":["18\u201054\u201054006"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Neurotoxins are among the main components of scorpion and snake venoms. Scorpion neurotoxins affect voltage\u2010gated ion channels, while most snake neurotoxins target ligand\u2010gated ion channels, mainly nicotinic acetylcholine receptors (nAChRs). We report that scorpion venoms inhibit \u03b1\u2010bungarotoxin binding to both muscle\u2010type nAChR from <jats:italic>Torpedo<\/jats:italic>\u00a0<jats:italic>californica<\/jats:italic> and neuronal human \u03b17 nAChR. Toxins inhibiting nAChRs were identified as OSK\u20101 (\u03b1\u2010KTx family) from <jats:italic>Orthochirus\u00a0scrobiculosus<\/jats:italic> and HelaTx1 (\u03ba\u2010KTx family) from <jats:italic>Heterometrus\u00a0laoticus<\/jats:italic>, both being blockers of voltage\u2010gated potassium channels. With an IC<jats:sub>50<\/jats:sub> of 1.6\u00a0\u03bc<jats:sc>m<\/jats:sc>, OSK1 inhibits acetylcholine\u2010induced current through mouse muscle\u2010type nAChR heterologously expressed in <jats:italic>Xenopus<\/jats:italic> oocytes. Other well\u2010characterized scorpion toxins from these families also bind to <jats:italic>Torpedo<\/jats:italic> nAChR with micromolar affinities. Our results indicate that scorpion neurotoxins present target promiscuity.<\/jats:p>","DOI":"10.1002\/1873-3468.13530","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T14:29:39Z","timestamp":1562336979000},"page":"2779-2789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Scorpion toxins interact with nicotinic acetylcholine receptors"],"prefix":"10.1002","volume":"593","author":[{"given":"Igor E.","family":"Kasheverov","sequence":"first","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences Moscow Russia"},{"name":"Institute of Molecular Medicine Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Oparin","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian 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