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The biosynthesis of these waxy lipids involves multiple enzymes, including thioesterase A (TesA). We observed that purified recombinant <jats:italic>M.\u00a0tuberculosis<\/jats:italic> TesA is able to dimerize in the presence of palmitoyl\u2010CoA and our 3D structure model of TesA with this acyl\u2010CoA suggests hydrophobic interaction requirement for dimerization. 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