{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:23Z","timestamp":1786976123841,"version":"build-2736575974"},"reference-count":116,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["A1\u2010S8696"],"award-info":[{"award-number":["A1\u2010S8696"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["C0013\u201000267746"],"award-info":[{"award-number":["C0013\u201000267746"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["S0016\u2010280365"],"award-info":[{"award-number":["S0016\u2010280365"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    The adenovirus E1B 55K (E1B) protein plays major roles in productive adenoviral infection and cellular transformation. Interest in E1B increased because of the potential of adenoviruses as therapeutic vectors, and the\n                    <jats:italic>E1B<\/jats:italic>\n                    gene is commonly deleted from adenovirus vectors for anticancer therapy. E1B activities are spatiotemporally regulated through\n                    <jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>\n                    ylation and phosphorylation, and through interactions with multiple partners that occur presumably at different intracellular sites and times postinfection. E1B is implicated in the formation of viral replication compartments and regulates viral genome replication and transcription, transcriptional repression, degradation of cellular proteins, and several intranuclear steps of viral late\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    biogenesis. Here, we review advances in our understanding of E1B during productive adenovirus replication and discuss fundamental aspects that remain unresolved.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.13694","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T11:22:44Z","timestamp":1574767364000},"page":"3504-3517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The biology of the adenovirus E1B 55K protein"],"prefix":"10.1002","volume":"593","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-0128","authenticated-orcid":false,"given":"Paloma","family":"Hidalgo","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Din\u00e1mica Celular Universidad Aut\u00f3noma del Estado de Morelos Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-1401","authenticated-orcid":false,"given":"Wing Hang","family":"Ip","sequence":"additional","affiliation":[{"name":"Heinrich Pette Institute Leibniz Institute for Experimental Virology Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-8588","authenticated-orcid":false,"given":"Thomas","family":"Dobner","sequence":"additional","affiliation":[{"name":"Heinrich Pette Institute Leibniz Institute for Experimental Virology Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-8529","authenticated-orcid":false,"given":"Ram\u00f3n A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Din\u00e1mica Celular Universidad Aut\u00f3noma del Estado de Morelos Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1731-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060201"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02417-08"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.11.9374-9379.1998"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.4.3146-3154.1998"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.07.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214882"},{"key":"e_1_2_8_9_1","first-page":"287","article-title":"Regulation of mRNA production by the adenoviral E1B 55\u2010kDa and E4 Orf6 proteins","volume":"272","author":"Flint SJ","year":"2003","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4507-4519.2002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90148-K"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90147-J"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.2.1115-1123.1997"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.future.2019.04.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.2.776-786.1994"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191361798"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.187"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.5.3620-3627.1997"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06066-11"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702158104"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00925-08"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01442-10"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13694"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90421-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02269-08"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.1.424-429.1991"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14004-14016.2005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-4-997"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18820-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.14.4276"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.9.6323-6335.1996"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00043-08"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002853"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203395"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.1.120"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.926401"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.190"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.01.013"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.50.1.202-212.1984"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.10.2552"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56597-7_2"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.2.964-974.2006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.2.470"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90088-9"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.06.016"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06764-11"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-4-575"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08360.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01725-06"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106955200"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02368-10"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02108-10"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00033-16"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.10.7960-7971.1998"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00170-08"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838200991994"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00074-10"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt064"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003775"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01836-15"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03387-12"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.153"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.21.9619-9629.2004"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.18.9194-9206.2002"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02134-10"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00029-07"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.534"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02034-17"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00089-09"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00402-19"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000781"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00527-0"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.11.3084"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01924-13"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.6.5495"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01113-09"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.7.5333-5344.1999"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.3.7.1212"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7707-7716.2004"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3465"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.11.7040-7050.1994"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1512"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.02.009"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01708-07"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00213-15"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.1.548-561.1997"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.9.7474-7488.1999"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/357082a0"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.17.2184"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.5.2944-2949.1993"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203316"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90356-7"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.15.5540-5553.2000"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208170"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.63"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.378"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1211039"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01608-06"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00440-11"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9479-9490.1998"},{"key":"e_1_2_8_102_1","first-page":"14","article-title":"The Mre11 cellular protein is modified by conjugation of both SUMO\u20101 and SUMO\u20102\/3 during adenovirus infection","volume":"2014","author":"Castillo\u2010Villanueva E","year":"2014","journal-title":"ISRN Virol"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003273"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10060"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13672"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-017-1488-1"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.08.069"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3290"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/14.4.380"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.2253-2262.1999"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.49.3.692-700.1984"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00469-14"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00863"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01739-7"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01091-15"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00164-18"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201741"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.13694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.13694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:57:06Z","timestamp":1694123826000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.13694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":116,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/1873-3468.13694"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.13694","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}