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However, the function of miRNAs is unclear in epithelial\u2013mesenchymal transition (EMT) of pterygium, a disease characterized by abnormal fibrovascular proliferation and invasion on the ocular surface. Since MiR\u20103175 is upregulated in pterygium tissues compared to normal conjunctival tissues, in this study, we investigated the role of MiR\u20103175 in EMT of a cultured human conjunctival epithelium cell line (CCL) and further validated the findings in pterygium tissues from patients. Our study demonstrates that MiR\u20103175 promotes proliferation, migration, invasion, and EMT of CCL cells by directly inhibiting Smad7. In conclusion, our data suggested that the MiR\u20103175\u2010Smad7 axis may play a critical role in pathogenesis and development of pterygium.<\/jats:p>","DOI":"10.1002\/1873-3468.13698","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T13:30:17Z","timestamp":1574861417000},"page":"1207-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["MiR\u20103175 promotes epithelial\u2010mesenchymal transition by targeting Smad7 in human conjunctiva and pterygium"],"prefix":"10.1002","volume":"594","author":[{"given":"Xincao","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Affiliated 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