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To date, these studies have shown that cell transformation is a multistep process regulated by the cooperation of several adenoviral gene products encoded in the early regions 1 (E1) and 4 (E4). Early region 1A immortalizes primary rodent cells, whereas co\u2010expression of early region protein 1B induces full manifestation of the transformed phenotype. Beside E1 proteins, also some E4 proteins have partial transforming activities through regulating many cellular pathways. Here, we summarize recent data of how adenoviral oncoproteins may contribute to viral transformation and discuss the challenge of pinpointing the underlying mechanisms.<\/jats:p>","DOI":"10.1002\/1873-3468.13717","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T14:52:04Z","timestamp":1575989524000},"page":"1848-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cell transformation by the adenovirus oncogenes E1 and E4"],"prefix":"10.1002","volume":"594","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-1401","authenticated-orcid":false,"given":"Wing Hang","family":"Ip","sequence":"first","affiliation":[{"name":"Heinrich Pette Institute Leibniz Institute for Experimental Virology Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dobner","sequence":"additional","affiliation":[{"name":"Heinrich Pette Institute Leibniz 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