{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:53Z","timestamp":1791434273530,"version":"4.3.3"},"reference-count":113,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Dengue disease is an inflammatory\u2010driven pathology, and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the AP, respectively. Thus, the pathology of severe dengue could in part result from AP dysfunction, even though complement and AP activation usually provide protection against viral infections. In dengue virus\u2010infected macrophages and endothelial cells (ECs), the site of replication and target for vascular pathology, respectively, the AP is activated. The AP activation, reduced FH and vascular leakage seen in dengue disease in part parallels other complement AP pathologies associated with FH deficiency, such as atypical haemolytic uraemic syndrome (aHUS). aHUS can be therapeutically targeted with inhibitors of complement terminal activity, raising the idea that strategies such as inhibition of complement or delivery of FH or other complement regulatory components to EC may be beneficial to combat the vascular leakage seen in severe dengue.<\/jats:p>","DOI":"10.1002\/1873-3468.13730","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T04:35:08Z","timestamp":1578976508000},"page":"2543-2555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Dengue virus and the complement alternative pathway"],"prefix":"10.1002","volume":"594","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-1472","authenticated-orcid":false,"given":"Jillian M.","family":"Carr","sequence":"first","affiliation":[{"name":"College of Medicine and Public Health Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Cabezas\u2010Falcon","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University Adelaide SA Australia"},{"name":"TGR Biosciences Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua G.","family":"Dubowsky","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod","family":"Hulme\u2010Jones","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-9685","authenticated-orcid":false,"given":"David L.","family":"Gordon","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University Adelaide SA Australia"},{"name":"SA Pathology Flinders Medical Centre Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1923"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07653-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403068"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.07.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1983.tb18116.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.09.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02627.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V122297"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02210310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080811"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfx081"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221549"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.028"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.63"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.01.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501536102"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110359"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109557"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.11.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60697-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2620"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v2.i3.56"},{"key":"e_1_2_7_27_1","first-page":"27","article-title":"An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document","volume":"33","author":"Campistol JM","year":"2013","journal-title":"Nefrologia"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.213"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60572-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19197.1"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2014010212"},{"key":"e_1_2_7_33_1","volume-title":"Dengue Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition","author":"WHO Organisation","year":"2009"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903869"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.324"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00062-06"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3863"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-8727-1_7"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3787"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006673"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005738"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-06"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20046"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.6.623"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.12.3.606-613.1975"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.5.763"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00994-19"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.185"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81199-0"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00257"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.12.045"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10323"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02799-06"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01352-08"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002586"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.12.022"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01117"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/309633a0"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.2.331"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02970145"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112220499"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00713-09"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1994.70"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.501"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.9.4376"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.11.061"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052388"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7466-7477.2005"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.07.007"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00276-11"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.11.007"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.015"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.09.003"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005277"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.03.008"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092545"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00912-16"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.137"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01561-08"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00056-12"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.10.5604-5611.2002"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1886"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605668103"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003513"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12184"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat7726"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197311082891902"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.569"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006782"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.01.022"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.66.366"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1086\/500949"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.05.005"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-209"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3010006"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2016.01.007"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01750"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.693119"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.702506"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00213-12"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00633-18"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002934"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02188-08"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000672"},{"key":"e_1_2_7_107_1","first-page":"37","article-title":"Regulation of complement gene expression","volume":"51","author":"Colten HR","year":"1986","journal-title":"Biochem Soc Symp"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.07.030"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-600411"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.07.028"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359646"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12129"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1443"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F1873-3468.13730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.13730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.13730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:11:34Z","timestamp":1693937494000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.13730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":113,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/1873-3468.13730"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.13730","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"2019-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}