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At the host\u2013pathogen interface, both cellular and humoral components of the innate immune system are increasingly acknowledged as essential players in the recognition and disposal of this opportunistic mold. Fundamental hereof is the contribution of the complement system, which deploys all three activation pathways in the battle against <jats:italic>A.\u00a0fumigatus<\/jats:italic>, and functionally cooperates with other soluble pattern recognition molecules, including pentraxins. In particular, preclinical and clinical observations point to the long pentraxin PTX3 as a nonredundant and complement\u2010dependent effector with protective functions against <jats:italic>A.\u00a0fumigatus<\/jats:italic>. Based on past and current literature, here we discuss how the complement participates in the immune response to this fungal pathogen, and illustrate its crosstalk with the pentraxins, with a focus on PTX3. Emphasis is placed on the molecular mechanisms underlying such processes, the genetic evidence from human epidemiology, and the translational potential of the currently available knowledge.<\/jats:p>","DOI":"10.1002\/1873-3468.13744","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T08:00:01Z","timestamp":1580284801000},"page":"2480-2501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The complement system in <i>Aspergillus\u00a0fumigatus<\/i> infections and its crosstalk with pentraxins"],"prefix":"10.1002","volume":"594","author":[{"given":"Raffaella","family":"Parente","sequence":"first","affiliation":[{"name":"Department of Immunology and Inflammation Humanitas Clinical and Research Institute \u2010 IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Doni","sequence":"additional","affiliation":[{"name":"Department of 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