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The microtubule motor proteins dynein and one or more kinesins are involved in this behavior. Dynein is implicated in adenovirus transport toward the nucleus. The kinesin Kif5B has now been found to move the adenovirus (AdV) toward microtubule plus ends, though a kinesin role in adenovirus\u2010induced nuclear pore disruption has also been reported. In undifferentiated cells, dynein\u2010mediated transport predominates early in infection, but motility becomes bidirectional with time. The latter behavior can be modeled as a novel assisted diffusion mechanism, which may allow virus particles to explore the cytoplasm more efficiently. Cytoplasmic dynein and Kif5B have both been found to bind AdV through direct interactions with the capsid proteins hexon and penton base, respectively. We review here the roles of the microtubule motor proteins in AdV infection, the relationship between motor protein recruitment to pathogenic\n                    <jats:italic>vs.<\/jats:italic>\n                    physiological cargoes, the evolutionary origins of microtubule\u2010mediated AdV transport, and a role for the motor proteins in a novel host\u2010defense mechanism.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.13777","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T03:34:12Z","timestamp":1585193652000},"page":"1838-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Role of cytoplasmic dynein and kinesins in adenovirus transport"],"prefix":"10.1002","volume":"594","author":[{"given":"Julian","family":"Scherer","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York NY 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