{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:14:49Z","timestamp":1791832489201,"version":"4.3.4"},"reference-count":84,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Factor H binding protein (fHbp) is a key virulence factor of <jats:italic>Neisseria\u00a0meningitidis<\/jats:italic> and a main component of the two licensed vaccines against serogroup B meningococcus (Bexsero and Trumenba). fHbp is a surface\u2010exposed lipoprotein that enables the bacterium to survive in human blood by binding the human complement regulator factor H (fH). When used as vaccine, the protein induces antibodies with potent bactericidal activity. While the <jats:italic>fHbp<\/jats:italic> gene is present in the majority of <jats:italic>N.\u00a0meningitidis<\/jats:italic> serogroup B isolates, the expression level varies up to 15 times between different strains and more than 700 different sequence variants have been described. Antigenically, the protein has been divided into three variants or two subfamilies. The 3D structure of fHbp alone, in combination with fH or in complex with bactericidal antibodies, has been key to understanding the molecular details of the protein. In this article, we will review the biochemical and immunological properties of fHbp, and its key role in meningococcal pathogenesis, complement regulation, and immune evasion.<\/jats:p>","DOI":"10.1002\/1873-3468.13793","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T20:12:52Z","timestamp":1587067972000},"page":"2657-2669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Meningococcal factor H binding protein as immune evasion factor and vaccine antigen"],"prefix":"10.1002","volume":"594","author":[{"given":"Silvia","family":"Principato","sequence":"first","affiliation":[{"name":"GSK Siena Italy"},{"name":"University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Pizza","sequence":"additional","affiliation":[{"name":"GSK Siena 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