{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:00:22Z","timestamp":1769860822947,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 157\u20102015"],"award-info":[{"award-number":["ALTF 157\u20102015"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["ECOST\u2010STSM\u2010Request\u2010CA15133\u201044200"],"award-info":[{"award-number":["ECOST\u2010STSM\u2010Request\u2010CA15133\u201044200"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) has become a major global challenge. The virus infects host cells using its spike glycoprotein (S\u2010protein) and has significantly higher infectivity and mortality rates among the aged population. Here, based on bioinformatic analysis, I provide evidence that some members of the upper respiratory tract (URT) commensal bacteria express viral S\u2010protein \u2010binding proteins. Based on this analysis and available data showing a decline in the population of these bacteria in the elderly, I propose that some URT commensal bacteria hamper SARS\u2010CoV\u20102 infectivity and that a decline in the population of these bacteria contributes to the severity of infection. Further studies should provide a better understanding of the interaction of URT bacteria and SARS\u2010CoV\u20102, which may lead to new therapeutic approaches.<\/jats:p>","DOI":"10.1002\/1873-3468.13845","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T20:26:21Z","timestamp":1590438381000},"page":"1651-1660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["SARS\u2010CoV\u20102 spike glycoprotein\u2010binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection"],"prefix":"10.1002","volume":"594","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-944X","authenticated-orcid":false,"given":"Kourosh","family":"Honarmand Ebrahimi","sequence":"first","affiliation":[{"name":"Chemistry Research Laboratory Department of Chemistry University of Oxford Oxford 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