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Besides, a minimal 8\u2010residue stretch in the QBP1 peptide (Ac\u2010WKWWPGIF\u2010am) is reported in the literature to retain this activity. Both peptides harbor a Pro\u2010Gly dipeptide motif, a feature characteristic of potential \u03b2\u2010turn regions. Here, we investigated whether the presence of this \u03b2\u2010turn motif is necessary for the inhibition of huntingtin aggregation, a polyglutamine protein implicated in Huntington\u2019s disease. Using single amino acid substitutions to generate analogs that could support, introduce, or eliminate the \u03b2\u2010turn, we show that the turn\u2010supporting motif is essential for QBP1\u2010mediated inhibition of huntingtin aggregation.<\/jats:p>","DOI":"10.1002\/1873-3468.13873","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T19:24:15Z","timestamp":1593285855000},"page":"2894-2903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The \u03b2\u2010turn\u2010supporting motif in the polyglutamine binding peptide QBP1 is essential for inhibiting huntingtin aggregation"],"prefix":"10.1002","volume":"594","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9929-2802","authenticated-orcid":false,"given":"Vinay Kumar","family":"Belwal","sequence":"first","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati 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