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While the E3 ubiquitin ligase TRAF\u2010interacting protein (TRIP) is known to play key regulatory roles in multiple diseases, its relevance in CM remains uncertain. In the present study, we found that TRIP overexpression is sufficient to inhibit the proliferation, invasion, and epithelial\u2013mesenchymal transition (EMT) of CM cells <jats:italic>in\u00a0vitro<\/jats:italic>, whereas the opposite phenotypes are observed following TRIP knockdown. We further determined that TRIP is able to promote the K48\u2010polyubiquitination of EMT\u2010associated transcription factor Twist\u2010related protein 1, thereby suppressing EMT progression. Together, our results suggest that TRIP plays an important role in regulating the progression of CM and that it may therefore be an important therapeutic target for the treatment of this disease.<\/jats:p>","DOI":"10.1002\/1873-3468.13882","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T20:40:57Z","timestamp":1594240857000},"page":"3170-3181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1"],"prefix":"10.1002","volume":"594","author":[{"given":"Chao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Second Hospital Cheeloo College of Medicine Shandong University Jinan 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