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We investigated p63 expression in SG regeneration induced by duct ligation and irradiation. The expression of \u0394Np63, a p63 isoform, increased and was colocalized with keratin 5 positive cells were myoepithelial cells. Furthermore, \u0394Np63 expression was regulated by FGF7 stimulation <jats:italic>via<\/jats:italic> p38 MAPK phosphorylation and affected SG morphogenesis. 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