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Pseudoxanthoma elasticum (PXE) International, an advocacy organization established by non\u2010scientists, began supporting research and convenings on these transporters, specifically ABCC6, the gene associated with PXE, 20\u00a0years ago. As a patient advocacy organization, we have spent more than 25\u00a0years creating a large research consortium, initiating, funding and conducting research. Years of basic modelling and vigorous hypothesis testing have resulted in some important advances leading to clinical trials. 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