{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:32:49Z","timestamp":1793035969974,"version":"4.5.0"},"reference-count":236,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The majority of proteins localised to mitochondria are encoded by the nuclear genome, with approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this fundamental cellular process is linked to a variety of pathologies including neuropathies, cardiovascular disorders, myopathies, neurodegenerative diseases and cancer, demonstrating the importance of mitochondrial protein import machinery for cellular function. Correct import of proteins into mitochondria requires the co\u2010ordinated activity of multimeric protein translocation and sorting machineries located in both the outer and inner mitochondrial membranes, directing the imported proteins to the destined mitochondrial compartment. This dynamic process maintains cellular homeostasis, and its dysregulation significantly affects cellular signalling pathways and metabolism. This review summarises current knowledge of the mammalian mitochondrial import machinery and the pathological consequences of mutation of its components. In addition, we will discuss the role of mitochondrial import in cancer, and our current understanding of the role of mitochondrial import in neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease.<\/jats:p>","DOI":"10.1002\/1873-3468.14022","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:17:49Z","timestamp":1607951869000},"page":"1107-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer"],"prefix":"10.1002","volume":"595","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-2400","authenticated-orcid":false,"given":"Catherine S.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and The Bio21 Molecular Science and Biotechnology Institute The University of Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and The Bio21 Molecular Science and Biotechnology Institute The University of Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-3222","authenticated-orcid":false,"given":"Diana","family":"Stojanovski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and The Bio21 Molecular Science and Biotechnology Institute The University of Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0092-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190126"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500298-MCP200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353883"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00536"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011320"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13116"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.809194"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.08.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.028"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.07.028"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014352"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.141267"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac6428"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180239"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1680-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0339-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708044"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.41.26844"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014918108"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.280446"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.19.7205-7213.2000"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/46802"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205613200"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.150"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400982"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413816200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3589"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6510"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19990701)74:1<11::AID-JCB2>3.0.CO;2-V"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.06.052"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06388-11"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120213"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16064"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.10.009"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0345-2"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.01.026"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00507-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.063818"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1569"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201105098"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2751"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01527-13"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq002"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.738146"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.33.21169"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00265-3"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.12.054"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15358"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124836"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2492-9"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201806093"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.053"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17463"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.013"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.014"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12450"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01665-8"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.11.014"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2141"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105313200"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312485200"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5966"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.07.018"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00400-w"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48828"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00150"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.08.064"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.04.020"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-12-0862"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1553"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12030"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0479555"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200707123"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-014-0292-7"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-020-0116-5"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa081"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-019-0714-1"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.02.062"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32540"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36372"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004311"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37823"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.03.020"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036657"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.92"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107000042"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2016_23"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn296"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.016"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010071"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708698"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12855"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23779"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv362"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv057"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a000786"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20180060"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.014"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0360-6"},{"key":"e_1_2_8_107_1","first-page":"4135","article-title":"Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early\u2010onset mitochondrial myopathy","volume":"27","author":"Pacheu\u2010Grau D","year":"2018","journal-title":"Hum Mol Genet"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22071"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0101-6"},{"key":"e_1_2_8_110_1","first-page":"45","article-title":"Extending the phenotypic spectrum of Sengers syndrome: congenital lactic acidosis with synthetic liver dysfunction","volume":"3","author":"Beck DB","year":"2018","journal-title":"Transl Sci Rare Dis"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003310"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0119-3"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.12.005"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.11.282"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.3233\/TRD-170017"},{"key":"e_1_2_8_116_1","first-page":"1","article-title":"Two novel mutations in the AGK gene: two case reports with Sengers syndrome","volume":"5","author":"Kor D","year":"2016","journal-title":"Gene Technol"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-177"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200483"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.4.257"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.6.1004"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/17135"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.09.020"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.09.004"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12348"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.10.008"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12792"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-017-0520-x"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001613"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.01.001"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.03.002"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2014-102961"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13452"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000420"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.141"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2015.1074332"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601276"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815587327"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.04.004"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12985"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12732"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00373"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.192138"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00342"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113613"},{"key":"e_1_2_8_145_1","first-page":"007","article-title":"Is beta\u2010amyloid accumulation a cause or consequence of Alzheimer's disease?","volume":"1","author":"Wang S","year":"2016","journal-title":"J Alzheimers Parkinsonism Dement"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200207030"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1469-06.2006"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806192105"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16-05-0313"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv241"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.07.024"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.492587"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.11.012"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.10.009"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.005"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.07.031"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080513"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120580"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-35"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2010"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.007"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008084"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.12.014"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911187107"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.161000"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.25884"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.10.041"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12748"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47352-9"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0470-7"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13418"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3097"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.02.012"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr048"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058435"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.01.002"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009399"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062277"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710012200"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1154-0"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3634"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00329"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904101116"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3721"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa185"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.001"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.22777"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2017.10.004"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25799"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2017.10.003"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.12.249"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.04.005"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051329"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3878-0"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22969"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-010-0228-3"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900380"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-004-3840-8"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0441"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1672"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25857"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.177"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21773"},{"key":"e_1_2_8_204_1","first-page":"1237","article-title":"The impact of TIMM17A on aggressiveness of human breast cancer cells","volume":"36","author":"Yang X","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.195339"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay1478"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1285-5"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42016"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407123"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-106"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0840-4"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15613"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22994"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3602"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4498-4"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2666"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68143"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4148-x"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5956-5-16"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00903"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12531"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58780"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310908110"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603455"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.928"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6515"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305051"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422222"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.210120"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2564"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-24"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207116"},{"key":"e_1_2_8_233_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3835"},{"key":"e_1_2_8_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65168-1"},{"key":"e_1_2_8_235_1","first-page":"5772","article-title":"JAK2\/STAT3 pathway as a therapeutic target in ovarian cancers","volume":"15","author":"Yoshikawa T","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_8_236_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17358"},{"key":"e_1_2_8_237_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001914200"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.14022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:12:16Z","timestamp":1693631536000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":236,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/1873-3468.14022"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14022","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"assertion":[{"value":"2020-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}