{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:14:27Z","timestamp":1793146467734,"version":"4.5.0"},"reference-count":226,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM118141"],"award-info":[{"award-number":["R35GM118141"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["MDA\u2010381828"],"award-info":[{"award-number":["MDA\u2010381828"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome, a by\u2010product of an ancient endosymbiotic event, mitochondria maintains a specialized and evolutionary divergent protein synthesis machinery, the mitoribosome. Mitoribosome biogenesis depends on elements encoded in both the mitochondrial genome (the RNA components) and the nuclear genome (all ribosomal proteins and assembly factors). Recent cryo\u2010EM structures of mammalian mitoribosomes have illuminated their composition and provided hints regarding their assembly and elusive mitochondrial translation mechanisms. A growing body of literature involves the mitoribosome in inherited primary mitochondrial disorders. Mutations in genes encoding mitoribosomal RNAs, proteins, and assembly factors impede mitoribosome biogenesis, causing protein synthesis defects that lead to respiratory chain failure and mitochondrial disorders such as encephalo\u2010 and cardiomyopathy, deafness, neuropathy, and developmental delays. In this article, we review the current fundamental understanding of mitoribosome assembly and function, and the clinical landscape of mitochondrial disorders driven by mutations in mitoribosome components and assembly factors, to portray how basic and clinical studies combined help us better understand both mitochondrial biology and medicine.<\/jats:p>","DOI":"10.1002\/1873-3468.14024","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T09:56:48Z","timestamp":1607767008000},"page":"1025-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The Diseased Mitoribosome"],"prefix":"10.1002","volume":"595","author":[{"given":"Alberto","family":"Ferrari","sequence":"first","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Del\u2019Olio","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine FL USA"},{"name":"Molecular and Cellular Pharmacology Graduate Program University of Miami Miller School of Medicine FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-3231","authenticated-orcid":false,"given":"Antoni","family":"Barrientos","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine FL USA"},{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64722-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(59)90094-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(63)80023-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/282368"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/2151340a0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96032-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96033-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249410"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251652"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal2415"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa3872"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13895"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1193"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258026"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58362"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/290457a0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2020.148275"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.007"},{"key":"e_1_2_10_20_1","first-page":"11423","article-title":"Human GTPBP10 is required for mitoribosome maturation","volume":"46","author":"Maiti P","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.01.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.066"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2456-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1053672"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170103"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.06.010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.04.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802608786141124"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.04.004"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.10.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280359"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.05.008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(04)77006-3"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02602907"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01936921"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01555"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/115.4.637"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1156"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa424"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.07.024"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.010"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks272"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2005.03.009"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202498200"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64139-5"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0373-y"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.12.030"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16503-2"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0709-7"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/222950a0"},{"key":"e_1_2_10_51_1","first-page":"1791","article-title":"Interaction of mammalian mitochondrial elongation factor EF\u2010Tu with guanine nucleotides","volume":"9","author":"Cai YC","year":"2000","journal-title":"Protein Sci"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17715-2"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18830-w"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.06.031"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04152"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn576"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815675116"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.06.028"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm441"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy221"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evv061"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2012.09.004"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00435-4"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.042"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838200001047"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014343"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00762-1"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609338113"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014402"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002390010093"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060089"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12890"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20282"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2008.04.004"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz093"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643391"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.031"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C114.581868"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-01-0014"},{"key":"e_1_2_10_80_1","article-title":"Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit","author":"Tobiasson V","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5570"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.06.030"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3464"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.006"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.005"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.030"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.033"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062608-160432"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073225"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-10-0636"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.363309"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100757"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004110"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku513"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.12.011"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.11.040"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.020"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq305"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1064"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694253"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa148"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz735"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-07-0643"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks257"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008923"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-09-0651"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1282"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.003"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64604"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.052365.115"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2017.1356551"},{"key":"e_1_2_10_112_1","article-title":"Role of GTPases in driving mitoribosome assembly","author":"Maiti P","year":"2020","journal-title":"Trends Cell Biol"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky672"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001784"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa592"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.515692"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.771105"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.04.002"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1132"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky701"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022567"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt490"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.08.004"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0793-289"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-013-9589-6"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1086\/301676"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi970962r"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.01.020"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.07.009"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203267200"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10012"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11091007"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.040"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101818"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.01.013"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00151-3"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008869"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.09.010"},{"key":"e_1_2_10_139_1","first-page":"1445","article-title":"Mutations in the MRPS28 gene encoding the small mitoribosomal subunit protein bS1m in a patient with intrauterine growth retardation, craniofacial dysmorphism and multisystemic involvement","volume":"28","author":"Pulman J","year":"2019","journal-title":"Hum Mol Genet"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-018-0561-9"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104880"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.012"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.03.026"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu747"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356060"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.06.007"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.053116"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.214"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-015-0440-6"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy098"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005089"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.07.005"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068340"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005679"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.May.18.6"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.327"},{"key":"e_1_2_10_157_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.20452\/pamw.2780","article-title":"The rs9982601 polymorphism of the region between the SLC5A3\/MRPS6 and KCNE2 genes associated with a prevalence of myocardial infarction and subsequent long\u2010term mortality","volume":"125","author":"Szpakowicz A","year":"2015","journal-title":"Pol Arch Med"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-017-1812-9"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy374"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21562"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101375"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-015-0444-2"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.091"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14067"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.04.014"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.006"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.17.17060"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019152"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23777"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/84808"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27132"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.013"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks910"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.03.010"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03130.x"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9415-4"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.07.010"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3113"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2016.1159381"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv481"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.08.009"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2017.05.005"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23985"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx314"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.03.001"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp208"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.027"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.12.007"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu288"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx152"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.02.013"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30311-1"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32180"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks774"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67457-w"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.015"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.09.014"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0222-5"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20821"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20768"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90113-L"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1086\/381133"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20305"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.01.007"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6934394"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9749457"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.6742"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.02.003"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.07.065"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004913"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b434"},{"key":"e_1_2_10_212_1","first-page":"454","article-title":"Association of primary open\u2010angle glaucoma with mitochondrial variants and haplogroups common in African Americans","volume":"22","author":"Collins DW","year":"2016","journal-title":"Mol Vis"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2019.0192"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17086-7"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02258374"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1299"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430116"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22307"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-220934"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400318"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng819"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5023-8"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-012-0322-0"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.03.010"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.589"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.07.007"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0074-5"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.14024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T23:55:15Z","timestamp":1724025315000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":226,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/1873-3468.14024"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14024","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]},"assertion":[{"value":"2020-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}