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Here, we found that DGK\u03b7 knockout markedly increased dopamine (DA) levels in the midbrain (DA\u2010producing region, 2.8\u2010fold) and cerebral cortex (DA projection region, 1.2\u2010fold). Moreover, DGK\u03b7 deficiency significantly augmented phosphorylated DA transporter (DAT) levels (1.4\u2010fold increase), which induce DA efflux to the synaptic cleft, in the cerebral cortex. Moreover, phosphorylation levels of protein kinase C\u2010\u03b2, which is activated by DG and involved in DAT phosphorylation, were also increased. DAT expressed in Neuro\u20102a cells recruited DGK\u03b7 to the plasma membrane and colocalized with it. 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