{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:45:16Z","timestamp":1785840316641,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Glucagon antagonism has been reported as a new therapeutic approach to hyperglycaemia. As the 14\u20103\u20103 protein YWHAB has been identified as a regulator of the glucagon receptor (GCGR) by affinity purification and mass spectrometry, we examined the role of YWHAB <jats:italic>in vivo<\/jats:italic>. <jats:italic>Ywhab<\/jats:italic> knockout mice display impaired blood glucose homeostasis only under pyruvate stimulation. Deletion of <jats:italic>Ywhab<\/jats:italic> in mouse primary hepatocytes (MPHs) increases hepatocyte glucose production by magnifying the effect of glucagon. Mechanistic analysis indicates that YWHAB forms a phosphorylation\u2010dependent complex with GCGR and directly interacts with forkhead box O1 (FOXO1). Together, these results reveal the inhibitory role of YWHAB in glucagon\u2010mediated hepatic glucose production, which may be a potential target for the control of gluconeogenesis and associated metabolic diseases.<\/jats:p>","DOI":"10.1002\/1873-3468.14063","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T12:27:01Z","timestamp":1614515221000},"page":"1275-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The 14\u20103\u20103 protein YWHAB inhibits glucagon\u2010induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1"],"prefix":"10.1002","volume":"595","author":[{"given":"Linlin","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of 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