{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:04:01Z","timestamp":1792119841871,"version":"4.4.0"},"reference-count":245,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Mitochondria play a key role in cellular signalling, metabolism and energetics. Proper architecture and remodelling of the inner mitochondrial membrane are essential for efficient respiration, apoptosis and quality control in the cell. Several protein complexes including mitochondrial contact site and cristae organizing system (MICOS), F<jats:sub>1<\/jats:sub>F<jats:sub>O<\/jats:sub>\u2010ATP synthase, and Optic Atrophy 1 (OPA1), facilitate formation, maintenance and stability of cristae membranes. MICOS, the F<jats:sub>1<\/jats:sub>F<jats:sub>O<\/jats:sub>\u2010ATP synthase, OPA1 and inner membrane phospholipids such as cardiolipin and phosphatidylethanolamine interact with each other to organize the inner membrane ultra\u2010structure and remodel cristae in response to the cell's demands. Functional alterations in these proteins or in the biosynthesis pathway of cardiolipin and phosphatidylethanolamine result in an aberrant inner membrane architecture and impair mitochondrial function. Mitochondrial dysfunction and abnormalities hallmark several human conditions and diseases including neurodegeneration, cardiomyopathies and diabetes mellitus. Yet, they have long been regarded as secondary pathological effects. This review discusses emerging evidence of a direct relationship between protein\u2010 and lipid\u2010dependent regulation of the inner mitochondrial membrane morphology and diseases such as fatal encephalopathy, Leigh syndrome, Parkinson's disease, and cancer.<\/jats:p>","DOI":"10.1002\/1873-3468.14089","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T08:01:12Z","timestamp":1618041672000},"page":"1159-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["MICOS and the mitochondrial inner membrane morphology \u2013 when things get out of shape"],"prefix":"10.1002","volume":"595","author":[{"given":"Indrani","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Cellular Biochemistry University Medical Center G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mausumi","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry University Medical Center G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-6951","authenticated-orcid":false,"given":"Michael","family":"Meinecke","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry University Medical Center G\u00f6ttingen Germany"},{"name":"G\u00f6ttinger Zentrum f\u00fcr Molekulare Biowissenschaften \u2013 GZMB G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0000000000000104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00296"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0052-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190126"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.04.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00633-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.04.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.06.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1.4.188"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605138"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.09.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2016.07.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11707"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0201-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105694"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014352"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.35"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.109728"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103621108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.05.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.3.221"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.05.037"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801697115"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2019.148091"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2020-0103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.020"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540152845885"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.09.038"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.598"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.2.269"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18853"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.012"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.01.001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.052705.163409"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24662"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.08.007"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101443"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2014.04.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30777"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201602007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.070"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.03.015"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9204"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.002"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.07.007"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6293"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01514"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201401006"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2433-7"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-09-0774"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171975"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06265"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06388-11"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.06.052"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277103"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.026"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.379"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201107053"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-10-0831"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.05.004"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12409"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.01.004"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11692-x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.755496"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034216"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.08.008"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvz111"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.10.009"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00338"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104237"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.10.006"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20346-2"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw250"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004361107"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.05.015"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949776"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2017.08.585"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.006"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.007"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201609046"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15258"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202003024"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2016.03.013"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07739"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019104105"},{"key":"e_1_2_9_87_1","first-page":"857","article-title":"ENTH domain\u2010dependent membrane remodelling","volume":"78","author":"Steinem C","year":"2020","journal-title":"Soft Matter"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00249\u2010021\u201001501\u2010z"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-08-0697"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200811099"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820364116"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3539"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.9.2253"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.102"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0345-2"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16064"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505496"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.387696"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00578-15"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47213-5"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.05.020"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.04.037"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.03.004"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063683"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17163"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160258"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506159"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-07-0545"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.03.037"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.01.002"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.004"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009282"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.01.026"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00046"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.05.008"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.007"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.015"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000943RR"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200809099"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3354"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006656"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx262"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006597"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.83"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038\u2010018\u20100442\u2010y"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30627"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu138"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx397"},{"key":"e_1_2_9_130_1","first-page":"1876","article-title":"CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10","volume":"52","author":"Huang X","year":"2018","journal-title":"Hum Mol Genet"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy413"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/806306"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.07.027"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24319"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70266-2"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000590"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.07.009"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb726"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00446-X"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127628"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1635"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28324"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55235-2"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080945"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01391-06"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.6.2026-2034.1991"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600798"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(71)90123-4"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2330"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.071233"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9601-4"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.134130"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201606069"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.615856"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00243.2006"},{"key":"e_1_2_9_156_1","first-page":"33","article-title":"Cardiolipin: biosynthesis, remodeling and trafficking in the heart and mammalian cells (Review)","volume":"1","author":"Hatch GM","year":"1998","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/709828"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536081"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(95)00024-X"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(91)90165-I"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.015"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000711"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12887"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.07.002"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06713.x"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225625"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.434183"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2625"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505478200"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-23"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-03-0256"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-016-4229-7"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.057"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505644"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2667"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69888-1"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.129174"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405479200"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz025"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909868199"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1700532"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2017.08.583"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722086115"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04456.x"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204593109"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-013118-110903"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.35"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512334200"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy231"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.07.014"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.198523"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404316200"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.07.059"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.03.006"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0633-y"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.08.004"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1372-3"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601184"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200704110"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0116"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.159186"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305584200"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200704112"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308006"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.021"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211311200"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.05.053"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi801723d"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.044933"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C112.406769"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919116117"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.025"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.021"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.07.010"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.049"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05655-x"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488349"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.124"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-32"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.08.015"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.02.024"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq007"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13031"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120213"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.24.7170"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-12-1023"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01753"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.032"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.6.1123"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401363200"},{"key":"e_1_2_9_231_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e17-03-0177"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200290034"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.11.008"},{"key":"e_1_2_9_234_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0239"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0214"},{"key":"e_1_2_9_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005920170018"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00329"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm079"},{"key":"e_1_2_9_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/79944"},{"key":"e_1_2_9_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/79936"},{"key":"e_1_2_9_241_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26716"},{"key":"e_1_2_9_242_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww212"},{"key":"e_1_2_9_243_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171439"},{"key":"e_1_2_9_244_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20660"},{"key":"e_1_2_9_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.11.007"},{"key":"e_1_2_9_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.08.041"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.14089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:12:32Z","timestamp":1693631552000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":245,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/1873-3468.14089"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14089","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}