{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:14:58Z","timestamp":1784945698199,"version":"3.55.0"},"reference-count":183,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008623","name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","doi-asserted-by":"publisher","award":["OCRC #20\u201015"],"award-info":[{"award-number":["OCRC #20\u201015"]}],"id":[{"id":"10.13039\/100008623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>SARS\u2010CoV\u20102 has infected hundreds of millions of people with over four million dead, resulting in one of the worst global pandemics in recent history. Neurological symptoms associated with COVID\u201019 include anosmia, ageusia, headaches, confusion, delirium, and strokes. These may manifest due to viral entry into the central nervous system (CNS) through the blood\u2013brain barrier (BBB) by means of ill\u2010defined mechanisms. Here, we summarize the abilities of SARS\u2010CoV\u20102 and other neurotropic RNA viruses, including Zika virus and Nipah virus, to cross the BBB into the CNS, highlighting the role of magnetic resonance imaging (MRI) in assessing presence and severity of brain structural changes in COVID\u201019 patients. We present new insight into key mutations in SARS\u2010CoV\u20102 variants B.1.1.7 (P681H) and B.1.617.2 (P681R), which may impact on neuropilin 1 (NRP1) binding and CNS invasion. We postulate that SARS\u2010CoV\u20102 may infect both peripheral cells capable of crossing the BBB and brain endothelial cells to traverse the BBB and spread into the brain. COVID\u201019 patients can be followed up with MRI modalities to better understand the long\u2010term effects of COVID\u201019 on the brain.<\/jats:p>","DOI":"10.1002\/1873-3468.14227","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:04:29Z","timestamp":1636560269000},"page":"2854-2871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neurological pathophysiology of SARS\u2010CoV\u20102 and pandemic potential RNA viruses: a comparative analysis"],"prefix":"10.1002","volume":"595","author":[{"given":"Nikhil","family":"Chakravarty","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thrisha","family":"Senthilnathan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Paiola","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Gyani","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Castillo Cario","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrella","family":"Urena","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Jeysankar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Jeysankar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ignatius Irudayam","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumathi","family":"Natesan Subramanian","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lavretsky","sequence":"additional","affiliation":[{"name":"Jane and Terry Semel Institute for Neuroscience and Human Behavior University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Gustavo","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-6141","authenticated-orcid":false,"given":"Arunachalam","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology University of California Irvine CA USA"},{"name":"Tata Institute for Genetics and Society Center at inStem Bangalore KA India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaithilingaraja","family":"Arumugaswami","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology University of California Los Angeles CA USA"},{"name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California Los Angeles CA USA"},{"name":"California NanoSystems Institute University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.29.925867"},{"key":"e_1_2_8_4_1","volume-title":"StatPearls","author":"Cascella M","year":"2021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-020-01412-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12010014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1614224"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28692"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.b.20087"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015908785777210"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.153"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/320941"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004845"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06927-11"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020244"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000074394.15882.83"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.025437"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1002.030638"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0519-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.11.1669"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-37"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-81-322-1777-0_6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050828"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030027"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81624-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1719902"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4067"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1271415"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.04.006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1408795"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0720-y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102799"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3502683"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/1755-6783.162654"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.2.16255"},{"key":"e_1_2_8_41_1","first-page":"247","article-title":"Virus\u2010induced autoimmune reactions in the CNS","volume":"253","author":"Talbot PJ","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.2.605"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4172\/2314-7326.1000201"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03925-1"},{"key":"e_1_2_8_46_1","first-page":"4221","article-title":"Neuropilin\u20111 as a new potential SARS\u2011CoV\u20112 infection mediator implicated in the neurologic features and central nervous system involvement of COVID\u201119","volume":"22","author":"Davies J","year":"2020","journal-title":"Mol Med Rep"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104384"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00174-9"},{"key":"e_1_2_8_50_1","first-page":"20264","article-title":"SARS\u2010CoV\u20102 and the secret of the furin site","volume":"2021","author":"Romeu AR","year":"2021","journal-title":"Preprints"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.09.031"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.102828"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000431"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009787"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.12.018"},{"key":"e_1_2_8_58_1","first-page":"22","article-title":"SARS\u2010CoV\u20102 infects brain astrocytes of COVID\u201019 patients and impairs neuronal viability","author":"Crunfli F","journal-title":"MedRxiv"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00240-0"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.003"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100127"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01347.x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2016"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0492-x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135530"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.001"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.002"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.01.005"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.028"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0331-4"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2065"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00262"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118102"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052824"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25915"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00028"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105131"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23171"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00404-18"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.2741\/3595"},{"key":"e_1_2_8_84_1","first-page":"eabc5801","article-title":"Non\u2010neuronal expression of SARS\u2010CoV\u20102 entry genes in the olfactory system suggests mechanisms underlying COVID\u201019\u2010associated anosmia","volume":"6","author":"Brann DH","year":"2020","journal-title":"SciAdv"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101839"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009153"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01443-1"},{"key":"e_1_2_8_88_1","first-page":"86","article-title":"Genomic characterisation of an emergent SARS\u2010CoV\u20102 lineage in Manaus: preliminary findings","volume":"14","author":"Faria NR","year":"2021","journal-title":"Virological"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.26.1.2002106"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.12.21.20248640"},{"key":"e_1_2_8_91_1","first-page":"932","article-title":"Convergent evolution of SARS\u2010CoV\u20102 spike mutations, L452R, E484Q and P681R, in the second wave of COVID\u201019 in Maharashtra, India","volume":"20","author":"Cherian S","year":"2021","journal-title":"Mol Biol"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.09.443299"},{"key":"e_1_2_8_93_1","first-page":"663","article-title":"SARS\u2010CoV\u20102 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination","volume":"44","author":"Hoffmann M","year":"2021","journal-title":"Mol Biol"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.08.443253"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab411"},{"key":"e_1_2_8_96_1","first-page":"777","article-title":"Reduced sensitivity of SARS\u2010CoV\u20102 variant Delta to antibody neutralization","volume":"8","author":"Planas D","year":"2021","journal-title":"Nature"},{"key":"e_1_2_8_97_1","unstructured":"Centers for Disease Control and Prevention.Variant Proportions. [cited 2021 Aug 18]. Available from:https:\/\/covid.cdc.gov\/covid\u2010data\u2010tracker\/#variant\u2010proportions."},{"key":"e_1_2_8_98_1","unstructured":"NavecaF daCostaC NascimentoF Costa\u00c1 DuarteDandSilvaG(2021)SARS\u2010CoV\u20102 reinfection by the new Variant of Concern (VOC) P.1 in Amazonas Brazil.Virological.https:\/\/virological.org\/t\/sars\u2010cov\u20102\u2010reinfection\u2010by\u2010the\u2010new\u2010variant\u2010of\u2010concern\u2010voc\u2010p\u20101\u2010in\u2010amazonas\u2010brazil\/596"},{"key":"e_1_2_8_99_1","first-page":"95","article-title":"Genomic epidemiology identifies emergence and rapid transmission of SARS\u2010CoV\u20102 B.1.1.7 in the United States","volume":"70","author":"Washington NL","year":"2021","journal-title":"Infect Dis"},{"key":"e_1_2_8_100_1","first-page":"359","article-title":"SARS\u2010CoV\u20102 B.1.1.7 and B.1.351 Spike variants bind human ACE2 with increased affinity","volume":"22","author":"Ramanathan M","year":"2021","journal-title":"Pathology"},{"key":"e_1_2_8_101_1","first-page":"94","article-title":"Increased Resistance of SARS\u2010CoV\u20102 Variants B.1.351 and B.1.1.7 to Antibody Neutralization","volume":"29","author":"Ho D","year":"2021","journal-title":"In Review"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.012"},{"key":"e_1_2_8_103_1","first-page":"921","article-title":"Acquisition of the L452R mutation in the ACE2\u2010binding interface of Spike protein triggers recent massive expansion of SARS\u2010Cov\u20102 variants","volume":"22","author":"Tchesnokova V","year":"2021","journal-title":"Microbiology"},{"key":"e_1_2_8_104_1","unstructured":"PANGO Lineages. [cited 2021 Jul 20]. Available from:https:\/\/cov\u2010lineages.org\/lineages\/lineage_B.1.617.html"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd3072"},{"key":"e_1_2_8_106_1","first-page":"173","article-title":"Delta spike P681R mutation enhances SARS\u2010CoV\u20102 fitness over Alpha variant","volume":"12","author":"Liu Y","year":"2021","journal-title":"Microbiology"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.28.446163"},{"key":"e_1_2_8_108_1","first-page":"12945","article-title":"Proteolytic activation of SARS\u2010CoV\u20102 spike protein","volume":"421","author":"Takeda M","year":"2021","journal-title":"Microbiol Immunol"},{"key":"e_1_2_8_109_1","article-title":"SARS\u2010CoV\u20102 B.1.617 emergence and sensitivity to vaccine\u2010elicited antibodies","author":"Ferreira I","year":"2021","journal-title":"bioRxiv"},{"key":"e_1_2_8_110_1","unstructured":"The Royal Society(2020)The SARS\u2010CoV\u20102 genome: variation implication and application. September 2020 DES7139.https:\/\/royalsociety.org\/\u2010\/media\/policy\/projects\/set\u2010c\/set\u2010c\u2010genome\u2010analysis.pdf"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.03.012"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02158"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix515"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00354-15"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01372-19"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00072-15"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.9.20720"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1808246"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.143768"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00206-17"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00952-17"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02557"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0100-y"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0060-z"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.12.005"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24345"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1323"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-018-0050-1"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02747"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.3648"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2019.1580827"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02576-12"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129629"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64493-8"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90303-4"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1006\/rwvi.1999.0144"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00065-15"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-7069(06)13005-0"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012374410-4.00428-3"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0148-6"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.04.029"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.06.007"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445852"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000287431.88658.8b"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0387-7"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20148"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32835fc601"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320509"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340307"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1143543"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199007000-00001"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199713000-00008"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600567"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.2.1750437"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.131"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0105-Rev"},{"key":"e_1_2_8_157_1","doi-asserted-by":"crossref","unstructured":"WadeBSC ValcourVG Wendelken\u2010RiegelhauptL Esmaeili\u2010FiridouniP JoshiSH&WangY(2015) Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort. In: 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI). Brooklyn NY USA: IEEE. [cited 2021 Jul 21]. p. 971\u20135. Available from:http:\/\/ieeexplore.ieee.org\/document\/7164033\/","DOI":"10.1109\/ISBI.2015.7164033"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5246"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-021-00548-z"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109393"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6805"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100484"},{"key":"e_1_2_8_163_1","first-page":"24839","article-title":"The Spectrum of Neuroimaging findings on CT and MRI in Adults with Coronavirus Disease (COVID\u201019)","volume":"20","author":"Moonis G","year":"2020","journal-title":"Am J Roentgenol"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117308"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-05178-y"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04946-w"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0961"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202222"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.029"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316822"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.054"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.10.002"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00949-5"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000446107"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20980"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00893.x"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-9-2151"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085953"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123016"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.06.002"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00818-15"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005120"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4444"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.14227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:20:40Z","timestamp":1693002040000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":183,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/1873-3468.14227"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14227","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"2021-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}