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These changes are mediated by parasite proteins that translocate beyond the parasitophorous vacuolar membrane in an unfolded state, suggesting protein folding by chaperones is imperative for the functionality of exported proteins. We report a type IV <jats:italic>P.\u2009falciparum<\/jats:italic> heat\u2010shock protein 40, PF11_0034, that localizes to the cytoplasmic side of J\u2010dots and interacts with the erythrocyte cytoskeleton, and therefore named eCiJp (erythrocyte cytoskeleton\u2010interacting J protein). Recombinant eCiJp binds to the human heat\u2010shock protein 70 HsHSPA1 and promotes its ATPase activity. In addition, eCiJp could suppress protein aggregation. Our data suggest that eCiJp recruits HsHSPA1 to the host erythrocyte cytoskeleton, where it may become involved in remodeling of the erythrocyte cytoskeleton and\/or folding of exported parasite proteins.<\/jats:p>","DOI":"10.1002\/1873-3468.14255","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T14:27:38Z","timestamp":1639146458000},"page":"95-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Plasmodium falciparum<\/i> HSP40 protein eCiJp traffics to the erythrocyte cytoskeleton and interacts with the human HSP70 chaperone HSPA1"],"prefix":"10.1002","volume":"596","author":[{"given":"Welka","family":"Sahu","sequence":"first","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapaswini","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritam Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Condensed Matter Theory Group Materials Theory Division Department of Physics and Astronomy Uppsala University Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archita","family":"Mazumder","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleena","family":"Das","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"},{"name":"Technology Business Incubator Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak Kumar","family":"Ojha","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh K.","family":"Verma","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvakumar","family":"Elangovan","sequence":"additional","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology Deemed to be University Bhubaneswar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-5250","authenticated-orcid":false,"given":"K. 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