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Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin\u2010dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue\u2010specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat\u2010specific genes, which are aggravated on high\u2010fat diet and during ageing. 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