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Yet, the cellular and physiological function of IRGC, a member of the IRG subfamily, has not been elucidated. Here, we show that testis\u2010specific IRGC is specifically and highly expressed in mature spermatozoa and is required for sperm motility. IRGC induction results in the clustering of lipid droplets and initiation of their physical contact with mitochondria. When examining clinical semen samples, IRGC expression is significantly lower in asthenozoospermia patients relative to healthy individuals. These unique effects of IRGC identify it as an important player in sperm motility, and show the potential of lipid metabolism\u2010targeting therapeutic intervention aimed at controlling asthenozoospermia.<\/jats:p>","DOI":"10.1002\/1873-3468.14640","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T13:50:24Z","timestamp":1684331424000},"page":"1595-1605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The immunity\u2010related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility"],"prefix":"10.1002","volume":"597","author":[{"given":"Jinyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University  China"},{"name":"Department of Genetics and Cell Biology, Basic Medical College Qingdao University  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