{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:43:31Z","timestamp":1784544211137,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970521"],"award-info":[{"award-number":["81970521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31170838"],"award-info":[{"award-number":["31170838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072421"],"award-info":[{"award-number":["81072421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    Homozygous mutations in the autoimmune regulator (\n                    <jats:italic>AIRE<\/jats:italic>\n                    ) gene that cripple thymic negative selection of autoreactive T cells result in autoimmune polyendocrinopathy\u2010candidiasis\u2010ectodermal dystrophy (APECED). However, how AIRE regulates the T\u2010cell response against foreign pathogens is not well understood. Here, we observed comparable primary CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells but a markedly reduced memory T\u2010cell population and protective function in Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice compared with wild\u2010type after infection with a strain of recombinant\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    . In adoptive transfer models, exogenous congenic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells transferred into Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice also showed a reduction in the memory T\u2010cell population, indicating an important role for extrathymic Aire\u2010expressing cells in shaping or sustaining memory T cells. Moreover, using a bone marrow chimeric model, we found that Aire expressed in radioresistant cells plays an important role in maintaining the memory phenotype. These results provide important insights into the role of extrathymic Aire in the T\u2010cell response to infection.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14696","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T14:34:15Z","timestamp":1688740455000},"page":"2185-2195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune regulator (Aire) deficiency results in reduced memory\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T cells after\n                    <i>Listeria monocytogenes<\/i>\n                    infection in a murine model"],"prefix":"10.1002","volume":"597","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-033X","authenticated-orcid":false,"given":"Yi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Guo","sequence":"additional","affiliation":[{"name":"Maternal &amp; Child Health Research Institute, Baoan Womens's and Children's Hospital, Jinan University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-399"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-393"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"ConstantineGMandLionakisMS(2019)Lessons from primary immunodeficiencies: autoimmune regulator and autoimmune polyendocrinopathy\u2010candidiasis\u2010ectodermal dystrophy.287 103\u2013120.","DOI":"10.1111\/imr.12714"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0176-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.4.397"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802124"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939918"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100212"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2011.01594.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362582"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60862"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58762"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.128"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01856.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0477-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535240"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.11.004"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181430"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl5053"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01247-6"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1009"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071641"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159407"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1427"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.005"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00051"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.06.010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06843.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03778.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T10:07:59Z","timestamp":1764497279000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":32,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/1873-3468.14696"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14696","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"2023-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}